Ab initio sequencing is a very important method in biopharmaceutical industry. It has important applications in the discovery of new candidate antibody drugs, the identification of reagents for research and the structure determination of innovative products in the development of bio generic drugs.
Technical introduction
Antibody sequencing is a direct de novo sequencing of antibody proteins without cell lines
Antibody sequencing using multi enzyme digestion, high resolution mass spectrometry and unique data analysis
Combining top-down and bottom-up mass spectrometry
Ensure the correctness of each amino acid and the sequence accuracy of the whole antibody, including N-terminal and C-terminal modifications and N-linked glycans
